Title of research project

Nanobubbles

Post doctoral Fellow: nanoparticle synthesis and characterisation for reproducible bionanoscience

Contract type Contrat (CDD) Category A Workload Fulltime

Scientific field Biochimie
Chimie
Matériaux

WorklJob Descriptionoad

Description of the offer Scientific context: The ERC Synergy NanoBubbles project is led by researchers from the Universities of Sorbonne Paris Nord, Maastricht, Grenoble-Alpes and Radboud, in collaboration with researchers from the CNRS, the University of Twente, IRIT and Ecole des Ponts (https://nanobubbles.hypotheses.org/). The project focuses on how, when and why science fails to correct itself. To understand how the correction of science works or fails, the NanoBubbles project combines approaches from the natural sciences (physics, chemistry, biology), engineering (natural language processing) and humanities and social sciences (linguistics, sociology, philosophy and history of science). Within that project sits the first replication initiative in nanobioscience, where we also pioneer in this field open science approaches (protocol, data and sample sharing, registered reports, etc). The scientific focus is the paradox of endosomal escape, i.e. on articles that report the use of nanoparticles as sensors of cytosolic intracellular targets in spite of the probable endosomal entrapment of those probes after cell uptake. We have recently completed the first replication and are currently completing the experimental phase of the second replication [1-4]. The NanoBubbles replication team is hosted in Bobigny in team 4 of the Laboratory for Vascular Translational Science (https://lvts.fr/). Objective: We are seeking to recruit a chemist with expertise in nanoparticle synthesis, functionalisation and characterisation to join the replication team. The chemist will work with a biologist to contribute to the replication of further articles. The objective is to shed light on the reproducibility of those articles, help solve the paradox of endosomal escape and contribute to the improvement of methods and approaches in this field. Given the nature of this project, we are looking for a meticulous person motivated to adhere to, and even develop, rigorous scientific standards. That person should also be enthusiastic about communicating with colleagues of very different disciplines. Qualifications we require: PhD in chemistry or material sciences. Experience: Experience in nanoparticle synthesis and characterisation. Experience in interactions of nanoparticles with biological systems. Previous post-doctoral experience is valued but not mandatory. Experience with handling and assembly of oligonucleotides is valued but not mandatory. References : [1] Mustafa Gharib, Maha Said, Thomas Pons, Nicole Hondow, Samia Zrig, and Raphaël Lévy. “Failed, Aborted Replication of ‘Carbon-Dot-Based Dual-Emission nanohybrid Produces a Ratiometric Fluorescent Sensor for In Vivo Imaging of Cellular Copper Ions.’” (2025) Preprint, Open Science Framework, https://doi.org/10.31219/osf.io/2x3hv_v3. [2] Maha Said, Mustafa Gharib, and Raphaël Lévy, Replication of “Nano-Flares: Probes for Transfection and mRNA Detection in Living Cells”, (2025) Preprint, Open Science Framework, https://doi.org/10.31219/osf.io/q8zsg_v4. [3] Emily Linnane, Cecilia Menard-Moyon and Yuki Yamada “Unsuccessful Replication of Cellular Copper Ion Imaging Using Carbon Dots.” (2025) Peer Community in Registered Reports, https://doi.org/10.24072/pci.rr.101070. [4] Cecilia Menard-Moyon “Are the Findings of ‘Nano-Flares: Probes for Transfection and mRNA Detection in Living Cells’ Reproducible?” (2025) Peer Community in Registered Reports, https://rr.peercommunityin.org/PCIRegisteredReports/articles/rec?id=962.

Field of research Bionanoscience, chemistry

Skills Nanoparticle synthesis, Nanoparticle functionalisation, Nanoparticle characterisation, Oligonucleotides handling

Knowledge

Work environment

Location Bobigny

Laboratory Laboratoire de Recherche Vasculaire Translationnelle (Laboratory for Vascular Translational Science)

Degree level

Degree required PhD in chemistry or material sciences

Experience required

WorkloadInformations complémentaires

Start date 04 20 26

Job Type Contrat (CDD)

Composition of the selection jury

Application deadline 02 20 26

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